Critical test evaluation of micronized mebendazole against Anoplocephala perfoliata in the horse

Critical test evaluation of micronized mebendazole against Anoplocephala perfoliata in the horse
Peer reviewed

Abstract

Mebendazole (methyl 5(6)benzoyl 1-2 benzimidazole carbamate) has recently been shown to have high anthelmintic efficacy against a wide range of benzimidazole-susceptible nematodes (Callear and Neave, 1971; Walker and Knight, 1972; Bennett, 1973; Bradley and Radhakrishnan, 1973; Neave and Callear, 1973; Reinecke and LeRoux, 1973). However, its activity against equine cestodes is generally reported to be unsatisfactory - e.g. Bradley and Radhakrishnan ( 1973) using mebendazole at a dose rate of 9 mg/kg (administered either per os or by stomach tube), did not observe significant anthelmintic efficacy against Anoplocephala spp. in horses. Similar results were reported by Drudge et al (1974) for mebendazole (8.8 mg/kg administered by stomach tube) against both Anoplocephala magna and A. perfoliata. Mebendazole is only sparingly soluble in water (and most organic and inorganic solvents) and is currently prepared for use as an aqueous suspension or as granulated dry feed…

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