Generalised ceroid-lipofuscinosis and brown bowel syndrome in Cocker spaniel dogs

Generalised ceroid-lipofuscinosis and brown bowel syndrome in Cocker spaniel dogs
Peer reviewed

Abstract

The ceroid-lipofuscinoses comprise a group of inherited storage diseases of human beings and animals that are characterised by progressive neurodegenerative disease and the accumulation within cells of a fluorescent lipopigment. A distinct syndrome occurs in Cocker spaniel dogs in which there is a generalised accumulation of a lipofuscin-like pigment, with such a heavy accumulation in smooth muscle that the intestine and other organs have a brown discolouration. Such discolouration is not observed in other forms of ceroid-lipofuscinosis. Dogs are clinically affected in adulthood and show progressive hind limb paresis, inco-ordination, and deficient postural reactions and proprioception. Spinal reflexes may be exaggerated. Behavioural or temperament changes, seizures or blindness may occur.

Access to the full text of this article is available:

through another providers website:

If you're a member or subscriber and believe you should have access:

Login

Otherwise:

Register for an account

Request new password

The whole of the literary matter of the New Zealand Veterinary Journal is copyright Taylor and Francis, Downloading this article signifies agreement with the terms and conditions of electronic access.