A zinc-containing intraruminal device for prevention of the sporidesmin-induced cholangiopathy of facial eczema in calves
New Zealand Veterinary Journal, Volume 49, Issue 1, pp 29-33, Feb 2001
Article class: Scientific Article
Subject Terms: Disease/defect, Fungal/yeast, Inflammation, Integument/skin/wool/hair/fur/feather, Liver/hepatic disease, Minerals/elememts, Mycotoxicosis, Photosensitivity, Toxicology, Trace elements, Treatment/therapyPublisher: Taylor and Francis
AbstractAIM: To develop and evaluate a zinc-containing intraruminal controlled-release bolus for protection of calves (175 - 250 kg bodyweight) against facial eczema (FE).
METHODS: Boluses releasing zinc, in the form of zinc oxide, at rates ranging from 1.67 to 4.25 g/day were administered to calves which were challenged 4 weeks later with the FE toxin, sporidesmin. The efficacy of the boluses in protecting against sporidesmin-induced cholangiopathy was determined by measuring serum activities of gamma-glutamyltransferase (GGT).
RESULTS: A bolus releasing zinc at approximately 4.25 g/day gave excellent protection against sporidesmin toxicity for periods of up to 5 weeks duration.
CONCLUSIONS: This zinc-containing intraruminal controlled-release bolus has the potential to markedly reduce the incidence and severity of FE in calves within a 175 - 250 kg bodyweight range.
KEY WORDS: facial eczema, calves, sporidesmin, zinc prophylaxis.
The whole of the literary matter of the New Zealand Veterinary Journal is copyright Taylor and Francis, Downloading this article signifies agreement with the terms and conditions of electronic access.