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Ectopic hepatocellular carcinoma in a dog
Burton IR, Limpus K, Thompson KG, Owen MC, Worth AJ
New Zealand Veterinary Journal, Volume 53, Issue 6, pp 465-467, Dec 2005
New Zealand Veterinary Journal, Volume 53, Issue 6, pp 465-467, Dec 2005
Article class: Clinical Communication
Animal Type: Companion animal, Dog
Subject Terms: Liver/hepatic disease, Neoplasia, Oncology, Pathology
Publisher: Taylor and FrancisAbstract
CASE HISTORY: A 14-year-old neutered male Bearded Collie was presented with a history of recurrent, intermittent urinary incontinence of 7 years duration.CLINICAL FINDINGS: A large, firm, non-painful mass was found in the mid-abdominal region on palpation. Ultrasonography of the mass revealed a compartmentalised structure with mixed echogenicity, and which did not appear to be associated with any of the abdominal organs. Ultrasound-guided fine needle aspirates contained several clusters of epithelial cells with cytological features of hepatocytes. At exploratory laparotomy, the mass was found in the gastrosplenic ligament within the greater omentum.
PATHOLOGICAL FINDINGS AND DIAGNOSIS: Histopathologically, the mass consisted of sheets of hepatocytes, but without the characteristic hepatic architecture. The cells showed moderate variation in nuclear size and were sometimes binucleate. A diagnosis of hepatocellular carcinoma (HCC) in the mesentery was made.
CLINICAL RELEVANCE: The presence of ectopic hepatic tissue has been reported rarely in man and cats, but not in the dog. Neoplastic transformation of ectopic hepatic tissue is seen in man. This is the first report of the presentation, clinical findings and treatment of a dog with ectopic HCC.
KEY WORDS: Dog, ectopic liver, hepatocellular carcinoma
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