Some histological lesions seen in macroscopically normal mesenteric lymph nodes of deer

Some histological lesions seen in macroscopically normal mesenteric lymph nodes of deer
Peer reviewed


Macroscopically normal mesenteric lymph nodes (MLN) were collected at approximately 25%, 50% and 75% of the full length of the MLN node chain from 80 deer killed at registered deer slaughter premises. Sections were incised at right angles to the node through the hilus.
In a number of MLN, focal macrophages within the cortex and medullary cords contained fine, granular and dense, irregularly sized material, which often had a pale brown appearance on H&E, black on a Ziehl-Neelsen stain and, very rarely, contained a red granule or crystal. The material was also positive to Sudan black and periodic acid Schiff and, to a variable extent, Perl’s stain. Some foci also contained crystalline-like material. On ultraviolet light examination of unstained sections the material emitted a golden yellow colour. These findings were indicative of a lipopigment and as they were more common in older deer were possibly age-related.
In the anterior MLN chain especially, there were calcified foci within germinal centres. This material often had a laminated appearance and generally no associated inflammatory response, although occasionally there was an associated multinucleated giant cell. Similar lesions in cattle have been considered to be post-reactive changes or due to parasites.

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