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DNA methylation events associated with the suppression of milk protein gene expression during involution of the bovine mammary gland : Brief Communication

DNA methylation events associated with the suppression of milk protein gene expression during involution of the bovine mammary gland : Brief Communication
Peer reviewed
Singh K, Swanson K, Couldrey C, Seyfert H-M, Stelwagen K
Proceedings of the New Zealand Society of Animal Production, Volume 69, pp 57-59, Jun 2009

Article class: Brief Communication

Animal Type: Cattle

Subject Terms: Diagnostic procedures, DNA/RNA, Genetics, Lactation, Mammary gland/udder, Milk, Protein

Publisher: New Zealand Society of Animal Production

Abstract

During lactation, prolactin activates STAT5 (Signal Transducer and Activator of Transcription), which binds to conserved DNA sequence motifs in promoters of milk protein genes to stimulate their expression (Liu et al., 1997). At drying-off, mammary involution is characterised by a rapid decrease in milk protein gene expression (Goodman & Schanbacher, 1991), including ?S1-casein (Singh et al., 2008). The ?S1-casein promoter features... Continued

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