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Understanding the interaction of prolactin and leukaemia inhibitory factor signalling during the switch from lactation to involution : Brief Communication

Understanding the interaction of prolactin and leukaemia inhibitory factor signalling during the switch from lactation to involution : Brief Communication
Peer reviewed
Singh K, Vetharaniam I, Prewitz M, Dobson J, Stelwagen K
Proceedings of the New Zealand Society of Animal Production, Volume 69, pp 65-67, Jun 2009

Article class: Brief Communication

Subject Terms: Animal production/wastage, Evidence/information based methods, Lactation, Mammary gland/udder, Milk, Molecular biology/medicine

Animal Type: Cattle

Publisher: New Zealand Society of Animal Production

Abstract

The molecular mechanisms involved in involution of the bovine udder, a process which underpins lactation persistency, are poorly understood. During rodent lactation, STAT5 is activated in response to prolactin (PRL) to stimulate milk protein production (Liu et al., 1997). At the onset of involution, STAT5 is rapidly inactivated (Schmitt-Ney et al., 1992), and STAT3 is activated by leukaemia inhibitory factor (LIF) to... Continued

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