Procaine penicillin by subconjunctival injection in the treatment of infectious bovine keratoconjunctivitis

Authors: Abeynayake P, Cooper BS
Publication: New Zealand Veterinary Journal, Volume 33, Issue 1-2, pp 6-7, Jan 1985
Publisher: Taylor and Francis

Animal type: Cattle, Livestock, Production animal, Ruminant
Subject Terms: Animal remedies/veterinary medicines, Antibiotics, Treatment/therapy, Bacterial, Eye/opthalmology, Inflammation, Disease/defect, Integument/skin/wool/hair/fur/feather, Clinical examination, Infectious disease, Rickettsia
Article class: Clinical Communication

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Abstract: A profile off the penicillin concentration in bovine conjunctival sac fluid (CF) was determined after a single subconjunctival injection of procaine penicillin (6 x 10⁵ iu in 2ml). When the injection was made through the skin of the upper eye lid, the duration of therapeutic concentration was significantly greater (P<0.01) than when the injection had been given by the perconjunctival route: approximately 68 hours or 40 hours respectively. These findings support the clinical use of subconjunctivally administered procaine penicillin in the treatment of infectious bovine keratoconjunctivitis. A single application of an equivalent dose of either procaine penicillin or benethamine penicillin, applied topically in a simple occulentum base, produced a therapeutic duration in CF of 37 ± 4 hr and 56 ± 4.5 hr respectively.

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