Chronic pain control in the dog: when NSAIDs just won't work

Authors: Mich PM
Publication: Proceedings of the Australian Veterinary Association (AVA) Annual Conferences, Volume 2014 AVA Annual Conference, Perth, Issue Integrative, May 2014
Publisher: Australian Veterinary Association

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Abstract: A Little Physiology: Chronic Pain and Neuromodulation Originally pain was perceived as a simple, predictable, proportional line of communication directly linking, without altering, pain signals as they are transmitted from the periphery to the brain for conscious perception. In the past 40 years the complexity of the somatosensory system is slowing unwinding. So far we know that pain pathways are highly labile and modulation in the periphery, the spinal cord, brainstem, and higher centers is the rule. From a simplified perspective peripheral nociception is altered by changes in threshold by inflammatory mediators and neuropeptides released from damaged tissue, which stimulate nociceptors, increase their sensitivity, recruit silent nociceptors, and result in up-regulation of receptors. The direct result is peripheral sensitization.

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