Cutaneous antigen-antibody reactions in the sheep

Authors: Vegad JL, Lancaster MC
Publication: New Zealand Veterinary Journal, Volume 20, Issue 7, pp 103-108, Jul 1972
Publisher: Taylor and Francis

Animal type: Livestock, Production animal, Ruminant, Sheep
Subject Terms: Integument/skin/wool/hair/fur/feather, Biochemistry/chemistry, Immune system/immunology
Article class: Scientific Article

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Abstract: It is clear that the early permeability response in the sheep that follows chemical and thermal injury, is mediated by histamine (Lancaster and Vegad, 1967; Vegad, 1971a, b). This is similar to the situation in the rat and the guinea-pig (Spector and Willoughby, 1965). In contrast to the situation in the rat and the guinea-pig, various nucleosides (Vegad, 197Oc), hyaluronidase (Vegad, 1970c), 5-hydroxytryptamine, turpentine-induced pleural exudates and the lymph node cell extracts also release histamine in the sheep skin (Vegad, 1967). From these results it was thought possible that cutaneous antigen-antibody reactions might also release histamine in the sheep, and this possibility has been investigated in the present experiments.

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