Field safety evaluation of cambendazole in horses

Authors: McMullan MJ, Griffiths OV, Horton FL
Publication: New Zealand Veterinary Journal, Volume 25, Issue 3, pp 69-70, Mar 1977
Publisher: Taylor and Francis

Animal type: Horse, Livestock
Subject Terms: Alimentary system/gastroenterology, Animal remedies/veterinary medicines, Anthelmintics, Parasite control, Parasites - internal, Nematode, Research/development, Treatment/therapy
Article class: Scientific Article

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Abstract: Cambendazole paste 31% w/w, at 20 and 40 mg/kg, was tested in a series of field trials involving 237 horses of various ages, sex and pregnancy status. No drug-related sequelae were observed except for a mild anorexia in 10 thoroughbreds in training and on concentrate feed. Forty-nine thoroughbred mares, more than three months pregnant, showed no drug-related sequelae to themselves or their foals. Of 10 dosed at 80 or 160 mg/kg, one (80 mg/kg) showed elevated temperature at 96 hours after dosing. Faecal egg counts were reduced 99% when conducted on 86 cambendazole treated animals seven to eight days after dosing at 20 or 40 mg/kg.

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