Immunological studies of sporidesmin: production of antibodies to azo-linked derivatives of 2-amino-5-chloro-3,4-dimethoxy benzyl alcohol

Authors: Jonas WE, Erasmuson AF
Publication: New Zealand Veterinary Journal, Volume 25, Issue 6, pp 161-164, Jun 1977
Publisher: Taylor and Francis

Animal type: Livestock
Subject Terms: Inflammation, Integument/skin/wool/hair/fur/feather, Disease/defect, Mycotoxicosis, Liver/hepatic disease, Fungal/yeast, Immune system/immunology, Photosensitivity, Toxicology
Article class: Scientific Article

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Abstract: 2-Amino-5-chloro-3,4-dimethoxy benzyl alcohol (ACDMBA), a compound similar to part of the substituted tryptophan in the sporidesmin molecule was synthetized. It was coupled to bovine gamma-globulin through azo linkages and used to immunize guinea-pigs and rabbits or coupled to various bacteria and used to immunize guinea-pigs. Antibodies to ACDMBA were demonstrated by a complement fixation test. Hapten-inhibition of complement fixation showed that the anti-ACDMBA antibodies cross-reacted with sporidesmin and some derivatives of sporidesmin.

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