A review of some modern equine anthelmintics

Authors: Scott P
Publication: New Zealand Veterinary Journal, Volume 25, Issue 12, pp 373-378, Dec 1977
Publisher: Taylor and Francis

Animal type: Horse, Livestock
Subject Terms: Alimentary system/gastroenterology, Animal remedies/veterinary medicines, Anthelmintics, Parasite control, Parasites - internal, Nematode, Treatment/therapy
Article class: Review Article

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Abstract: Thiabendazole was the first of several benzimidazole anthelmintics and was superior to previously available drugs in both efficiency and safety. Of the “second generation” of benzimidazoles, mebendazole and cambendazole are widely used in horses and provide wider efficacy spectra and lower dose rates compared with thiabendazole. Thiabendazole has proven activity against larval strongyles, but requires high dose rates. Two organophosphates, dichlorvos and haloxon have been formulated as horse anthelmintics. Pyrantel and its analogue morantel, are reported as efficient equine anthelmintics, but only in-feed and paste formulations are recommended by the manufacturer as suitable for horses. Strains of small strongyles tolerant to benzimidazoles have been reported in U.S.A. and U.K. The addition of a piperazine salt to approximately half recommended dose rate, or the use of pyrantel, removed the tolerant nematodes.

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