The anthelmintic activity of some benzimidazole derivatives against Fasciola hepatica

Authors: Chevis RAF, Kelly JD
Publication: New Zealand Veterinary Journal, Volume 26, Issue 9, pp 218-220, Sep 1978
Publisher: Taylor and Francis

Animal type: Livestock
Subject Terms: Alimentary system/gastroenterology, Animal remedies/veterinary medicines, Anthelmintics, Parasite control, Parasites - internal, Liver/hepatic disease, Trematode, Pharmacology, Treatment/therapy
Article class: Scientific Article

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Abstract: Micronised mebendazole has been shown to have anthelmintic activity against Fasciola hepatica in rats and sheep. Activity is higher against non-egg-producing F. hepatica in bile ducts than against the migrating larval stages. Parbendazole, cambendazole and thiabendazole have been shown to be much less active, or devoid of activity, against mature and immature F. hepatica in rats, at elevated dose rates. Reasons for the differences, in terms of molecular structure, are briefly discussed and the pitfalls of structure/activity analyses are considered.

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