Experimental canine herpesvirus infection in newborn puppies, using a New Zealand isolate

Authors: Durham PJK, Poole WSH
Publication: New Zealand Veterinary Journal, Volume 27, Issue 1-2, pp 14-16, Jan 1979
Publisher: Taylor and Francis

Animal type: Companion animal, Dog
Subject Terms: Disease transmission, Epidemiology, Viral, Disease/defect, Infectious disease, Neonatal, Research/development
Article class: Scientific Article

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Abstract: A New Zealand canine herpesvirus isolate was inoculated into three 2-day-old puppies via the intraperitoneal route, two other puppies from the same litter being retained as in-contact controls. All pups were left suckling the bitch. One inoculated pup died of misadventure. The remaining inoculated pups, and one in-contact pup, died with clinical signs of herpesvirus infection, the virus being subsequently recovered from a number of tissues. The remaining in-contact pup also developed typical disease, but recovered, virus being detected only in the tonsils. Lesions were detected in the diseased puppies in a wide variety of organs, and were consistent with previously published reports. No evidence of disease was detected in the bitch, but both she and the recovered pup developed neutralizing antibodies to the virus.

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