Leptospira interrogans serovar pomona vaccines with different adjuvants in cattle

Authors: Hamel KL, Ris DR
Publication: New Zealand Veterinary Journal, Volume 27, Issue 8, pp 169-171, Aug 1979
Publisher: Taylor and Francis

Animal type: Cattle, Livestock, Production animal, Ruminant
Subject Terms: Animal remedies/veterinary medicines, Bacterial, Clinical pathology, Diagnostic procedures, Immune system/immunology, Zoonosis, Disease/defect, Infectious disease, Research/development, Vaccination, Public health
Article class: Scientific Article

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Abstract: Three groups of four heifers were vaccinated twice, 11 weeks apart. One group received a commercial pomona vaccine with aluminium hydroxide adjuvant, the second a similar experimental vaccine, and the third a Freund`s compete adjuvant (FCA) vaccine. After 47 weeks, the heifers were challenged with at least 65 x 10⁸ virulent serovar pomona organisms. All vaccinated animals resisted the challenge, and leptospirae were only found in urine from unvaccinated controls. The outcome of the challenge was not predictable from microscopic agglutination, cold and warm complement fixation, and growth inhibition titres. The FCA vaccine gave rise to considerably higher antibody responses than the two aluminium hydroxide vaccines, which gave similar responses.

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