Protection of sheep by vaccination against artificial challenge with Leptospira interrogans serovar hardjo

Authors: Marshall RB, Hathaway SC, Broughton ES
Publication: New Zealand Veterinary Journal, Volume 27, Issue 9, pp 195-196, Sep 1979
Publisher: Taylor and Francis

Animal type: Livestock, Production animal, Ruminant, Sheep
Subject Terms: Animal remedies/veterinary medicines, Bacterial, Clinical pathology, Diagnostic procedures, Immune system/immunology, Zoonosis, Disease/defect, Infectious disease, Vaccination, Public health
Article class: Scientific Article

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Abstract: The hardjo component of a bivalent pomona/hardjo vaccine was evaluated, using sheep. Nine sheep were vaccinated and 10 remained unvaccinated. All sheep were challenged with an intraperitoneal and intramuscular injection of a hardjo culture. After 13 weeks, the sheep were slaughtered and their kidneys cultured for leptospires. There was a highly significant difference between the culture results from the two groups (p<0.001); 10/10 (100%) of the unvaccinated animals gave positive cultures compared with 2/9 (22%) of the vaccinates.

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