The oesophageal-groove reflex and anthelmintic efficacy

Authors: Hepburn JF
Publication: New Zealand Veterinary Journal, Volume 29, Issue 3, pp 39-40, Mar 1981
Publisher: Taylor and Francis

Animal type: Livestock
Subject Terms: Abdomen, Alimentary system/gastroenterology, Animal remedies/veterinary medicines, Anthelmintics, Parasite control, Parasites - internal, Treatment/therapy
Article class: Correspondence

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Abstract: In reply to Dr Charleston`s letter, the following points are pertinent. The pharmacokinetics of any drug are the chief parameters which determine its efficacy and safety and hence its ultimate usefulness as a therapeutic or prophylactic agent. In the case of the benzimidazole class of anthelmintics it has been shown that one very important factor in ensuring their efficacy is the prolongation of contact time between drug and parasite. The requirement that this contact be prolonged for as long as possible is a consequence of the mode of action of this group…

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