Suspected inherited cerebellar neuroaxonal dystrophy in collie sheep dogs

Authors: Cameron JS, Clark RG, Burgess GS, Hartley WJ, Mitchell G
Publication: New Zealand Veterinary Journal, Volume 30, Issue 7, pp 102-103, Jul 1982
Publisher: Taylor and Francis

Animal type: Companion animal, Dog
Subject Terms: Locomotor, Disease/defect, Genetics, Inherited disease/conditions, Nervous system/neurology
Article class: Scientific Article

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Abstract: A cerebellar neuroaxonal dystrophy in working collie sheep dogs from two properties in New Zealand and one property in Australia is described. Clinical signs developed from 2-4 months of age and included hypermetria, wide-based stance, difficulty in maintaining balance, intention tremor and ataxia. Numerous spheroids, associated with mild Wallerian degeneration, were present in the central cerebellar, adjacent peduncular and folia white matter, and associated cerebellar roof and lateral vestibular nuclei. The history of several affected pups in litters from successive matings of the same sire and dam is suggestive of an autosomal recessive mode of inheritance.

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