Protection of piglets against a virulent New Zealand isolate of Aujeszky's disease virus by vaccination with a novel genetically-engineered vaccine

Authors: Motha MXJ, Oliver RE, Worthington RW, Poole WS, Penrose ME
Publication: New Zealand Veterinary Journal, Volume 36, Issue 2, pp 100-101, Jun 1988
Publisher: Taylor and Francis

Animal type: Livestock, Pig, Production animal
Subject Terms: Animal remedies/veterinary medicines, Genetics, Immune system/immunology, Vaccination, Viral
Article class: Correspondence

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Abstract: Genetic engineering techniques have enabled novel Aujeszky`s disease virus (ADV) vaccines to be developed by specific deletions in viral genes. Kit developed a first generation ADV vaccine by deletion of the thymidine kinase gene from the Bucharest strain of ADV. This vaccine has been shown to be safe and effective for vaccinalting pigs against ADV and is licensed for use in the United States with over 1 000 000 doses sold. A second generation ADV vaccine has been developed by Kit from the first generation vaccine by deletion of the glycoprotein III gene. Deletion of the glycoprotein III gene makes it possible to differentiate pigs infected with field strains of ADV from vaccinated pig using serological tests. The ability of this second generation genetically-engineered ADV vaccine…

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