Clearance of ovine isolates of Bordetella parapertussis from murine trachea and lungs

Authors: Manktelow BW, Chen W, Alley MR
Publication: New Zealand Veterinary Journal, Volume 39, Issue 2, pp 75-76, Jun 1991
Publisher: Taylor and Francis

Animal type: Laboratory animal, Livestock, Production animal, Ruminant, Sheep
Subject Terms: Bacterial, Respiratory system, Disease/defect, Infectious disease, Ear/nose/throat
Article class: Short Communication

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Abstract: Thirty-six mice were inoculated intranasally with Bordetella parapertussis organisms (isolated from sheep with chronic non-progressive pneumonia) to study their deposition and clearance in the lower respiratory tract. The deposition of the organism was greater in the trachea than in the lungs. At 48 hours after inoculation, almost 100% of organisms were cleared from the trachea but only 55% of organisms were cleared from the lungs. This result correlates well with the morphological changes seen previously in the pulmonary parenchyma and airways of mice and lambs experimentally infected with this organism.

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