A comparison of the efficacy of two commercial Aujeszky's disease vaccines with glycoprotein-I deletion in pigs

Authors: Tham KM, Horner GW, Ralston JC, Motha MJX
Publication: New Zealand Veterinary Journal, Volume 41, Issue 1, pp 1-6, Mar 1993
Publisher: Taylor and Francis

Animal type: Livestock, Pig, Production animal
Subject Terms: Animal remedies/veterinary medicines, Treatment/therapy, Viral, Disease/defect, Infectious disease, Immune system/immunology, Vaccination
Article class: Scientific Article

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Abstract: Two commercial Aujeszky`s disease vaccines, a modified killed vaccine and a sub-unit vaccine, both carrying a deletion of glycoprotein-I, were evaluated in pigs. Each vaccine was administered to two groups of four pigs, twice at 4-week intervals, with two pigs held as unvaccinated controls. All pigs were challenged with a New Zealand field isolate of Aujeszky`s disease virus 3 weeks after the second vaccination. The results indicate that the sub-unit vaccine was able to protect pigs against clinical Aujeszky`s disease much better than the pigs vaccinated with the modified killed vaccine when challenged with a virulent virus. However, the amount and the duration of virulent virus excretion following challenge was greater with the sub-unit vaccine than the modified killed vaccine. Pigs vaccinated with the sub-unit vaccine were shown to be latently infected following challenge. Latent infection was demonstrated by excretion of Aujeszky`s disease virus from the nasal cavity after dexamethasone treatment and seroconversion of a sentinel in contact pigs to Aujeszky`s disease virus.

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