Efficacy of doramectin against experimental infections by some nematode parasites in cattle in New Zealand

Authors: Hooke FG, Hosking BC, Watson TG
Publication: New Zealand Veterinary Journal, Volume 43, Issue 2, pp 67-69, Apr 1995
Publisher: Taylor and Francis

Animal type: Cattle, Livestock, Production animal, Ruminant
Subject Terms: Alimentary system/gastroenterology, Animal remedies/veterinary medicines, Anthelmintics, Parasite control, Parasites - internal, Treatment/therapy, Nematode
Article class: Scientific Article

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Abstract: A study was undertaken to determine the efficacy of the novel avermectin, doramectin, against experimental larval and adult infections of three species of nematode parasite important to cattle production in New Zealand. Eighteen worm-free dairy bull beef calves were randomly allocated on live weight to three similar treatment groups. Each calf was given 30 000 Ostertagia ostertagi, 20 000 Cooperia spp. and 10 000 Trichostrongylus axei infective larvae as a single dose. One group was treated with doramectin 6 days after infection while the remaining groups received saline or doramectin 27 days after infection. Given as a single subcutaneous injection behind the ear, doramectin at 200 ug/kg removed 99.9-100% of adult and larval stages of 0. ostertagi, Cooperia spp. and T. axei when compared to infections established in untreated controls (p<0.001). No adverse reactions were observed following treatment in the doramectin-treated animals. No injection site lesions were found by palpation following treatment or by injection site examination at necropsy,

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