Observations on hypoglycaemia associated with a hepatoma in a cat

Authors: Johnstone AC, Jones BR, Thompson JC, Hickson PC
Publication: New Zealand Veterinary Journal, Volume 43, Issue 5, pp 186-189, Oct 1995
Publisher: Taylor and Francis

Animal type: Cat, Companion animal
Subject Terms: Biochemistry/chemistry, Clinical pathology, Diagnostic procedures, Liver/hepatic disease, Neoplasia, Oncology
Article class: Clinical Communication

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Abstract: Disorientation, muscle fasciculations and weakness seen in a 12-year-old neutered female domestic shorthaired cat were attributed to hypoglycaemia associated with a large hepatoma. Glucagon tolerance tests on this cat and a healthy cat showed that their plasma glucose concentrations increased and decreased at about the same rate. Plasma insulin concentrations in the healthy cat increased and decreased in parallel with the plasma glucose concentration. In the affected cat, plasma insulin concentrations increased initially but decreased more rapidly. Reflecting these observations, the amended insulin to glucose ratios in the affected cat were much lower than those of the healthy cat, until the 4-hour sample. Serum somatostatin, somatomedin and gastrin concentrations were measured but no conclusions as to pathogenesis of the hypoglycaemia could be made. The alterations in insulin secretion in the affected cat suggested that altered hormonal control of glucose homeostasis may have occurred with this tumour.

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