Possible therapeutic effect of chlorpromazine on canine pancreatitis resulting from organophosphate toxicosis

Authors: Dalefield R, Fickbohm B, Oehme FW
Publication: New Zealand Veterinary Journal, Volume 47, Issue 2, pp 75-76, Apr 1999
Publisher: Taylor and Francis

Animal type: Companion animal, Dog
Subject Terms: Nervous system/neurology, Toxicology, Alimentary system/gastroenterology, Abdomen, Parasites - external, Pest/pesticides, Poisoning - chemical, Treatment/therapy
Article class: Correspondence

---

Abstract: Acute pancreatitis as a complication of organophosphate (OP) toxicosis has been described in human beings (Dressel et al., 1979; Hsaio et aZ., 1996), dogs and guinea pigs (Frick et al., 1987). This complication may be more common than the number of clinical reports might suggest, as it can be painless (Hsaio et al., 1996). The administration of OPs increases pressure in the canine pancreatic duct in vivo and causes hypersecretion, hyperamylasaemia and hyperlipasaemia. Pancreatic lesions observed within 2 hours of OP administration included a grossly apparent interstitial oedema and, histologically, acinar cell vacuolation. These lesions were transient under the experimental conditions, as they were not apparent at 72 hours, but a mild lymphocytic infiltrate was observed in the pancreas of one dog at 72 hours (Dressel et al., 1996). The responses of the canine pancreas in vivo to diazinon were subsequently compared to those in cat and guinea pig pancreata. No pathological lesions were observed in feline pancreata at 2,3 or 6 hours after OP administration. However in dog pancreata, vacuolation of the acinar cells, interstitial edema and vasculitis were observed after 3 hours. Vasculitis and interstitial edema were…

---