Osseous lesions resembling vaccine-site sarcomas in two cats (abstract)

Authors: Jerram RM, Bastianello SS, Opie CL, Thompson KG
Publication: New Zealand Veterinary Journal, Volume 52, Issue 1, pp 49, Feb 2004
Publisher: Taylor and Francis

Animal type: Cat, Companion animal
Subject Terms: Animal remedies/veterinary medicines, Skeletal/bone/cartilage, Immune system/immunology, Trauma/injuries, Meat, Neoplasia, Oncology, Pathology, Vaccination
Article class: Abstract

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Abstract: Lytic lesions with microscopic features similar to those of vaccine site sarcomas were diagnosed in the distal femur of two young neutered male cats, one a 20-month-old Birman and the other an 18-month-old domestic short-hair (DSH). Radiographically, there was extensive destruction of trabecular and cortical bone in the metaphysis and/or epiphysis of the distal femur. The DSH cat also had angular deformity of the distal femur due to asymmetrical involvement of the physis. Histologically, the lesions in both cats consisted of dense, interwoven bundles of fibrous connective tissue, amongst which there were variable numbers of plump malignant mesenchymal cells, often with very large, hyperchromatic nuclei and irregularly shaped nucleoli. Several focal aggregates of small lymphocytes were present in both tumours. Although neither cat had apparently been vaccinated in the hindlimb it is possible that the tumours had been triggered by injection of some other irritant material.

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