Development of an arterial thrombosis model in pigs for investigating the thrombogenicity of different dietary fats (abstract)

Authors: Maccoll AJ, James KAC, Thompson KG, Arthur DG
Publication: New Zealand Veterinary Journal, Volume 41, Issue 1, pp 46, Mar 1993
Publisher: Taylor and Francis

Animal type: Livestock, Pig, Production animal
Subject Terms: Circulatory system/haematology, Diet/rations/food, Fat/lipids, Disease/defect, Nutrition/metabolism, Research/development
Article class: Abstract

---

Abstract: A surgically induced model of arterial thrombosis in pigs (60-80 kg live weight) has been developed using a balloon angioplasty technique. The purpose of this model is to assess the thrombogenicity of milkfat in comparison with other dietary lipids, thereby assessing its importance in the pathogenesis of human coronary heart disease. Balloon angioplasty catheters (Meditech, 3 cm X 8 mm balloon) are inserted into the left and right femoral arteries via a cut-down on to the saphenous artery. The balloons are inflated five times for 30 seconds with 30 second intervals between inflations. This results in endothelial denudation, exposure of sub-endothelial connective tissue and formation of platelet rich thrombi. Thrombus size is quantitated using autologous blood platelets labelled with ⁹⁹Tc-HMPAO (technetium - “Deretec”).
An initial study has been designed to compare the thrombogenicity of milkfat with coconut oil, which is high in saturated fatty acids, and fish oil, which is rich in omega-3 polyunsaturated fatty acids.

---