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The development of multiple cutaneous inverted papilloma following ovariohysterectomy in a dog

Authors: French AF, Munday JS, MacNamara AR
Publication: New Zealand Veterinary Journal, Volume 58, Issue 3, pp 168-171, Jun 2010
Publisher: Taylor and Francis

Animal type: Dog
Subject Terms: Disease/defect, Husbandry/husbandry procedures, Infectious disease, Integument/skin/wool/hair/fur/feather, Neoplasia, Oncology, Surgery, Viral
Article class: Clinical Communication
Abstract:

 

CASE HISTORY: Ovariohysterectomy was performed on an adult Cavalier King Charles Spaniel. The skin that had been clipped for surgery was noticed to be erythematous 8 days later.
CLINICAL AND PATHOLOGICAL FINDINGS: Poorly defined patches containing multiple papules were visible bilaterally within the clipped skin. These became larger over the following 2 weeks, and samples were collected for histology. Seven days later, the lesions were multiple raised masses, up to 5 cm in diameter. Histology revealed numerous cup-shaped epidermal proliferations extending into the dermis. The presence of keratinocytes with increased quantities of blue-grey cytoplasm, and koilocytosis suggested papillomaviral infection; Canis familiaris papillomavirus (CfPV-2) DNA was amplified from two separate samples. Complete regression was observed 8 weeks after the lesions had been initially observed.
DIAGNOSIS: Multiple inverted papilloma confined to skin that had been clipped for surgery.
CLINICAL RELEVANCE: This is the first time that the development of canine cutaneous papillomas has been associated with surgery. The nature of the association between surgery and development of the papillomas is uncertain. However, it is possible that damage to superficial skin could promote the formation of papillomas. This is the first identification of CfPV-2 in New Zealand.

KEY WORDS: Inverted papilloma, papillomavirus, surgery, skin, New Zealand, dog

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